Street Meds for Cancer? Repairing the Liver After Fenbendazole
Fenbendazole, known on the street as “dog de-wormer for cancer,” has been very effectively advertised for its anti-cancer effects. Social media has let this urban legend loose to the point where it gained high hopes and very high-profile attention. Even Joe Rogan, the world’s biggest broadcaster by far, recently touted it on a podcast for shrinking tumors. But there are some misconceptions that Mr. Rogan missed, not having worked at a natural cancer clinic as I have for the past 17 years. First, fenbendazole is an OTC veterinary medicine and is, therefore, subject to much looser quality control than human pharmaceuticals. Because this is being sold by third-party vendors on the internet, that are fenbendazole’s biggest cheerleaders, it is your guess as to what exactly is in the capsules you receive, and at what concentration, after exactly what kind of quality control. What has been missing from the public conversation is that fenbendazole’s mechanism against cancer is in the context of a weak chemotherapy drug. Like vinblastine and vincristine, it disrupts microtubule formation and microtubule activity. [1] The drug’s target is the molecule tubulin, which helps provide the skeletal foundation of microtubules necessary in cell replication—for both normal and cancer cells. Cancers reproduce faster than normal tissue, so a long-standing chemotherapy strategy has been to create damage to cellular replication, which injures cancer cells earlier than it injures normal cells, but it does injure all kinds of cells. Ask the Vet: Protect Dog From Intestinal Parasites With Monthly Dewormer Hyperbaric Oxygen Therapy’s Promising Potential in Cancer Treatment At first, fenbendazole’s effect on disrupting the cell cycle looked effective in the lab mice. [2] But then, sacrificing mice to examine tumors is not quite the same as taking responsibility for human cancer patients to get well, to survive their cancers, and to stay in remission long-term. For a cancer patient to rely on anything—especially one monomolecular approach—that does not work effectively against cancer wastes valuable time. Doing that attacks cancer only strongly enough to make it mutate. Just like giving too little antibiotic to bacteria, giving a mild chemotherapy like fenbendazole to a cancer patient buys time for the tumor to become resilient to this gentle nudge. The net result usually strengthens existing cancer. It is one of the worst strategies against cancer, from what I have seen over the years. The other problem is that fenbendazole has not had positive effects on the liver. There are reports in the medical literature of people damaging their livers with this drug, driving the liver enzymes alanine transaminase (ALT) and aspartate aminotransferase (AST) into the several-hundred range but then reversing the alarming liver blood labs on discontinuation of the drug. [3] ALT and AST are each supposed to be less than 40, and around the teens or 20s would be nice. This new liver toxicity may even have the potential to promote new cancer in the liver. [4] The liver toxicity of another hepatotoxicant, acetaminophen, is increased when fenbendazole is added. [5] Besides liver damage, this study of fenbendazole use with pigeons showed multiple organ damage. [6] It should come as no surprise that fenbendazole and its metabolites mildly poison the liver. The related drugs mebendazole and albendazole are already known to have metabolites that are toxic to human livers [7] by means of cholestatic liver injury [8] and in dose-dependent effects. [9] This is why the usual course of mebendazole treatment in humans is only two days. Why not consider those treatments primarily that do not have a toxic profile before considering ones with little confirmed effect and are known to have a concerning toxic profile? Joe Rogan did get ivermectin for COVID exactly right [10] and has likely thereby saved countless lives due to his enormous reach. But I must disagree with him regarding the use of fenbendazole for cancer on the basis of its unimpressive track record and, primarily, the tenet of "first do no harm." [10] COVID-19 Treatment Research. Ivermectin for COVID-19: 230 ivermectin COVID-19 studies, 177 peer-reviewed, 99 comparing treatment and control groups. https://c19ivm.org/
Publish Date : 2023-11-17 20:20:18
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