Disitamab vedotin by Seagen for Urethral Cancer: Likelihood of Approval
Disitamab vedotin by Seagen for Urethral Cancer: Likelihood of Approval
Disitamab vedotin is under clinical development by and currently in Phase II for Urethral Cancer. According to GlobalData, Phase II drugs for Urethral Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase II. Smarter leaders trust GlobalData The gold standard of business intelligence. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Disitamab vedotin overview Disitamab vedotin (Aidexi) is an antibody-conjugated drug that contains the human epidermal growth factor receptor-2 (HER2) antibody portion, linker and the cytotoxic drug monomethyl auristatin E (MMAE). It is developed based on antibody-drug conjugates technology. It is formulated as solution for injection for intravenous route of administration. Aidexi is indicated for the treatment of locally advanced or metastatic gastric cancer (including gastroesophageal junction adenocarcinoma) with HER2 over-expression in patients who have received at least two types of systemic chemotherapy. Disitamab vedotin (RC-48) is under development for the treatment of solid tumors including breast cancer, HER2 expressing non-small cell lung cancer, non-muscle invasive bladder cancer (NMIBC), metastatic liver cancer, advanced or metastatic urothelial carcinoma of unresectable origin including urothelial carcinoma of bladder, ureter cancer, renal pelvis cancer, and urethral cancer, advanced melanoma, advanced or metastatic HER2 expressing biliary tract cancer, bile duct cancer, gallbladder cancer, muscle invasive bladder cancer (MIBC) HER2 expressing u metastatic cholangiocarcinoma, HER2 expressing gastric cancer, gastro-esophageal junction cancer or gastroesophageal junction adenocarcinoma and refractory HER2 low expressing metastatic breast cancer, HER2 positive and negative breast cancers, cervical cancer, epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, endometrial cancer, vulvar cancer, vaginal cancer, metastatic colorectal cancer, salivary gland tumor, head and neck squamous cell carcinoma, esophageal carcinoma, metastatic castration resistant prostate cancer (mCRPC), oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer and primary sarcoma of the gynecological reproductive system. It is a recombinant humanized anti-HER2 monoclonal antibody-monomethyl auristatin E (MMAE) antibody-drug conjugate administered through intravenous and intravenous drip routes in the form of powder for solution. The drug candidate acts by targeting the human epidermal growth factor receptor 2 (Her2). The drug candidate is developed based on antibody-drug conjugates technology. It was also under development for the treatment of ovarian cancer and bladder cancer Seagen overview , formerly Seattle Genetics, is a biotechnology company focused on the discovery, development, and commercialization of monoclonal antibody-based therapies for the treatment of cancer. The company markets antibody-drug conjugates (ADCs) designed to target specific types of cancer. These includes Adcetris (brentuximab vedotin), for the treatment of Hodgkin’s lymphoma, T-cell lymphomas, and CD30 expressing lymphomas; Padcevtm (enfortumab vedotin-ejfv) for metastatic urothelial cancers; Tukysa (tucatinib) for the treatment of metastatic HER2-positive breast cancers, and Tivdak (tisotumab vedotin-tftv) for the treatment of certain metastatic cervical cancers. The company’s pipeline consists of novel therapies for addressing the unmet medical needs in blood-related cancers and solid tumors. products and pipeline are based on ADC technology and SEA technology which targets monoclonal antibodies and delivers agents for killing cancer cells. The company sells its products through specialty distributors. is headquartered in Bothell, Washington, the US. For a complete picture of Disitamab vedotin’s drug-specific PTSR and LoA scores, This content was updated on 9 October 2023 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s . Smarter leaders trust GlobalData The gold standard of business intelligence.
Publish Date : 2023-10-27 21:50:59
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